Metronomic chemotherapy, which is defined by the frequent, repetitive administration of chemotherapeutic drugs at relatively low doses, and without prolonged drug-free break, is an emerging strategy to fight cancer. Initially thought to act by targeting tumour angiogenesis, additional mechanisms have been recently unveiled and metronomic chemotherapy is now considered to represent a form of multi-targeted therapy. Despite representing a genuine alternative for advanced and/or high-risk (…)