Searching for “metronomic" in PubMed lead to the identification 99 publications in 2015. More publications on the topic including those using for instance the term “low dose chemotherapy” are therefore not included in this analysis. The paediatric publications are very limited with only 7 papers published in 2015. Moreover, 4 are pre-clinical studies, one looked at angiogenic biomarkers during the maintenance of children with leukaemia and 3 are case reports. Most of the publications deals (...)