Metronomics Global Health Initiative
About it
Articles
- Drug Repositioning
- Immunomodulation and antiangiogenesis in cancer using metronomic chemotherapy. New therapeutic paradigm
- Metronomic Chemotherapy
- Metronomic chemotherapy : publications on the rise !
- Metronomics
- Metronomics for low income countries : the word is spreading !
- Metronomics Global Health Initiative
- Metronomics Global Health Initiative : Ensemble pour le développement de nouvelles stratégies anticancéreuses durables pour les enfants des pays en voie de développement.
- Metronomics in 2015
- Reflections from an Expert about Communicating the Initiative
- 全球健康行动倡议
Web sites
Dreams
Articles
Events
Sections
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PAST EVENTS
- Pediatric Oncology Symposium in Brazil (INTCR-TUCCA-Consulat Général de France )
- ALTERNATIVE ETHICAL STRATEGIES FOR GLOBAL HEALTH IN DEVELOPING COUNTRIES.
- International Symposium of Metronomic Chemotherapy - Update on Multimodality Mechanisms including Immunotherapeutic Aspects
- Mathematical Models of Tumor-Immune System Dynamics
- Metronomic at 2013 WIN SYMPOSIUM
- Metronomics at the SAIC-SAFIS 2013 in Argentina
- Metronomics@Mumbai 2016: M@M 2016
- MGHI at the 8th meeting of the Société Marocaine d’Hématologie et d’Oncologie Pédiatrique
- MGHI at the Conference of New Ideas in Cancer: Challenging dogmas—Tata Memorial Centre Platinum Jubilee
- PHOCON-2012, 16th Annual Pediatric Haematology Oncology Conference
- Present Challenges of Mathematics in Oncology and Biology of cancer
- Target Meeting’s 2nd World Cancer Online Conference
- 1st LATIN AMERICAN MEETING IN METRONOMIC CHEMOTHERAPY AND DRUG REPOSITIONING IN ONCOLOGY
- 2nd Annual Workshop on Cancer Systems Biology-Tumor Metronomics: Timing and Dose Level Dynamics July 17-20, 2012, Tufts University, Medford Campus (Boston, MA), USA
- 2nd workshop in metronomic chemotherapy (March 2010-Marseille)
- 3rd Metronomic Angiogenic Meeting (22nd-23rd March 2012, Haifa)
- 4th Metronomic Chemotherapy Meeting-Milano 2014
- 36th EORTC-PAMM 2015 : Time for paradigm shifts in oncology ?
- UPCOMING
News items
- program of the 6th metronomic available
- Milano Metronomic Meeting : final program
- A new supporter from Brazil and pictures from the MGHI team at the Nice Cannes Marathon
- Milano Metronomic Meeting 2014
- EcancerTV interview of Pr Banavali
- MGHI at the marathon of Arles
- Report of the Systems Biology Second Annual Workshop on metronomics has been published in Cancer Resarch
- Pictures of the 2nd Annual Workshop on Cancer Systems Biology-Tumor Metronomics
- Pictures of the 3rd metronomic meeting have been added !
- 8ème congrès de la Société Marocaine d’Hématologie et d’Oncologie Pédiatrique
- 3rd metronomic meeting in Haifa : final program
- 3rd metronomic meeting : call for abstracts
- Program of the 3rd Metronomic Angiogenic Meeting
- 3rd Metronomic Angiogenic Meeting
Media
Articles
- Interview of E. Pasquier about propranolol & neuroblastoma
- Is Cancer Care Is Too Expensive For Poor Countries ?
- ’We Can, We Should, We Will Conquer Cancer’
- Abandonment of Treatment
- ASCO launches the Journal Of Global Oncology
- Bob Kerbel Interview in ETHealthWorld
- Cancer in developing countries (ESO e-grandround)
- Cancer joins AIDS, malaria as global health issue
- Cancer treatment ain’t just for the rich
- Death of Evangelos Briassoulis (1953-2016)
- E. Pasquier in the World Today (ABC Australia)
- ET HEALTHWORLD INTERVIEW OF DR EDDY PASQUIER
- Frugal Innovation in Medicine
- Global move needed to battle cancer in poor countries
- Global Oncology (GO!) interview of Nicolas ANDRE
- High-level Meeting on Non-communicable Diseases
- INSERM highlights the potential of beta-blockers for angiosarcoma
- interview of Dr Bhattacharyya at on metronomic at ASCO2013
- JE SUIS CHARLIE
- Launch of the : Drug Repurposing, Rescue, and Repositioning journal
- Metronomic Chemotherapy and the immune system: Pr David Waxman on ETHealthWord.com
- Metronomics : A Financial Orphan Therapy ?
- Metronomics for paediatric brain tumours at ISPNO 2018
- Metronomics hilighted in the press in India
- Metronomy is the next generation targeted therapy: Dr Shripad D. Banavali on ETHealthWord.COM
- MGHI "Prays for Paris"
- MGHI on Facebook
- MIA In The War On Cancer: Where Are The Low-Cost Treatments?
- Pr T Kutluk opening speech at the UN General Assembly High-Level Meeting on the comprehensive review and assessment of the progress achieved in the prevention and control of NCD
- Research and Development to Meet Health Needs in Developing Countries: Strengthening Global Financing and Coordination Report Consultative Expert Working Group on Research and Development of the WHO
- The cancer drugs in your bathroom cabinet (The Guardian)
- The Repurposing Drugs in Oncology (ReDO) project
- Yuval Shaked ETHealthWorld.com interview: Cancer will not be a disease in the next 100 years
Sections
News items
Partners
Articles
- Ahimsa Partners
- Assistance Publique des Hôpitaux de Marseille
- Foundation for a New Ethical Business
- L’ETOILE DE MARTIN
- Reliable Cancer Therapies
- Sourire A La Vie
- Tata Memorial Hospital
- TUCCA
- University of New South Wales
News items
People
Sections
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Ambassadors
- Bishal Gyawali
- Dr G. S. Bhattacharyya
- Anna TOWN
- Arnauld VERSCHUUR
- Babak ABDOLKARIMI
- Barton KAMEN (1949-2012)
- Bhawna SIROHI
- Bishnu D. PAUDEL
- Dr Kelvin K. TSAI
- Dr. Chi-kong LI
- DR. Lawrence OSEI-TUTU
- Evangelos BRIASOULIS (1953-2016)
- Giannoula LAKKA KLEMENT
- Giselle SAULNIER SHOLLER
- Guido BOCCI
- Jaroslav STERBA
- Jean-François DE LAVISON
- Laila HESSISSEN
- Lisa HUTCHINSON
- Mark KIERAN
- Michael RETSKY
- O. Graciela SCHAROVSKY
- Paul Charles DELAPEYRE
- Pierre MOTTET
- Pr Amany MOHAMED ALI
- Pr LEUNG Ping Chung
- Robert KERBEL
- Scott HOWARD
- Shripad BANAVALI
- Sidnei EPELMAN
- Traore FOUSSEYNI
- Urszula LEDZEWICZ
- Vinod RAINA
- Yuliya SNIHUR
- Yuval SHAKED
- Founders
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Supporters
- Sébastien BENZEKRY
- Andreza Almeida Senerchia
- Barbara BILLER
- Brendan BOOSTROM
- Brendan GUERCIO
- DR Ramaswami KARTIK
- Dr Sidharth K TODARI
- Elisabeth CHOURAKI
- Giuseppe CURIGLIANO
- Herman Andrés PERROUD
- John EBOS
- Marcello DELITALA
- Maria El Kababri
- Martin VILLALBA GONZALEZ
- Nicolas-Xavier VON DER WEID
- Paul FITZGERALD
- Pr Hemonta Kr. DUTTA
- Prabhat S. MALIK
- Richard KAST
- Sybille VAN DEN HOVE
- Wendy Cristhyna Gómez GARCIA
News items
- new ambassador from Nepal
- First Ambassador from Greece
- Our first amabassador from Italy
- A new supporter from Harvard at MGHI
- A new ambassador from the USA at MGHI
- A new supporter from Dominican Republic at MGHI
- a new ambassador from India at MGHI
- A new ambassador at MGHI
- Barton Kamen died on Sept. 27, 2012
- An new supporter at MGHI
- A new Ambassador from India at MGHI
- A new supporter from India at MGHI
- A new supporter from India at MGHI
- A new Ambassador at MGHI
- A new ambassador from Belgium
- a new supporter from Argentina !
- An new Ambassador at MGHI
- A new ambassador at MGHI !
- A new supporter at MGHI
- Two New Ambassadors at MGHI
- New Supporter
- New Ambassador at MGHI
- New Metronomic People at MGHI
Projects
Sections
- Completed
- In preparation
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On-going
- Chimiothérapie Métronomique et " les 10 ans du Cancéropole PACA"
- Dose-Finding of Propranolol in combination with metronomic fixed oral cyclophosphamide based on Bivariate efficacy-tolerability outcome in patients with locally advanced or metastatic angiosarcoma : A collaborative and innovative phase I-II sequential trial
- Drug repositioning- Frontiers in Oncology-call for papers
- FLUVABREX : Combination of 2 oral agents for refractory Low Grade Glioma
- Metro-Mali02
- Metro-SFCE01
- MGHI and GFAOP agreed to work on a metronomic project
- Société Marocaine d’Hématologie et Oncologie Pédiatrique-Metro01 phase 2 trial
- the International School of Metronomic Chemotheray - ISMe
- the MGHI metronomics in LMIC survey
- Update about the Moroccan Society of Pediatric Hematology/Oncology Phase II metronomic trial.
- Update about the pediatric palliative and metronomic program in Dominican Republic
Sections
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BARTON KAMEN PRIZE
- Barton Kamen-MGHI Prize : call for abstract
- First Barton Kamen-MGHI prize : Modified COMBAT (Combined Oral Metronomic Biodifferentiating Antiangiogenic Treatment) therapy in poor prognosis pediatric malignant brain tumors
- Metronomic therapy can increase quality of life during paediatric palliative cancer care, but careful patient selection is essential.
- Second Barton Kamen-MGHI prize: call for abstract
- The 2nd Barton Kamen-MGHI Prize has been attributed to Pr G. Saulnier-Sholler : DFMO in Neuroblastoma
- 3rd Karton Kamen-MGHI Prize : call for abstracts
News items
Publications
Sections
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MGHI papers
- Challenges and opportunities for cancer clinical trials in low- and middle-income countries
- Pilot study of a pediatric metronomic 4-drug regimen
- A mathematical model for the administration of temozolomide: comparative analysis of conventional and metronomic chemotherapy regimens.
- Access to new drugs in paediatric oncology: can we learn from the ongoing ONC201 saga?
- Accidental Poisoning With 6-MP in a Sibling of Pediatric Patient Treated With Metronomic Maintenance Chemotherapy.
- Beta-blockers disrupt mitochondrial bioenergetics & increase radiotherapy efficacy independently of BAR in medulloblastoma
- Can metronomic maintenance with weekly vinblastine prevent early relapse/progression after bevacizumab–irinotecan in children with low-grade glioma?
- Can Targeted Therapy be Successful without Metronomic Scheduling ?
- Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells
- Covid19: breaking bad news with social distancing in pediatric oncology
- Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-Based Metronomic Chemotherapy: A Bench to Bedside Study
- Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma
- Has the time come for metronomics in low-income and middle-income countries?
- Herbal Medicine Offers Great Potential in Support of Metronomic Cancer Therapy
- Highlights from the 1st Latin American meeting on metronomic chemotherapy and drug repositioning in oncology
- Investment in cancer studies in countries of low and middle income
- Irinotecan dose schedule for the treatment of Ewing sarcoma—protracted/metronomic schedule—wording
- Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting
- Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect
- METRO-PD1: Phase 1 study of nivolumab in combination with metronomic chemotherapy in children and adolescents with relapsing/refractory solid tumors
- Metronomic chemotherapy for children in low- and middle-income countries: survey of current practice and opinion of pediatric oncologists," has been accepted for publication in Journal of Global Oncology
- Metronomic Chemotherapy in Pediatric Oncology: A Way Forward for Low-Income Countries?
- Metronomic Chemotherapy with the COMBAT Regimen in Advanced Pediatric Malignancies: A Multicenter Experience
- Metronomic Chemotherapy: Direct Targeting of Cancer Cells after all?
- metronomic maintenance for locoregionally advanced nasopharyngeal carcinoma
- Metronomic Maintenance Therapy for Rhabdomyosarcoma
- Metronomic Maintenance With Weekly Vinblastine After Induction With Bevacizumab-Irinotecan in Children With Low-grade Glioma Prevents Early Relapse
- Metronomic metformin and propranolol combination prevents cancer progression and metastasis in breast cancer
- Metronomic reloaded: Theoretical models bringing chemotherapy into the era of precision medicine.
- Metronomic Scheduling of Anticancer Agents for a Refractory Orbital Pseudotumor in a Child
- Metronomic Scheduling of Anticancer Treatment The Next Generation Of Multitarget Therapy?
- Metronomics : India showing the way !
- Metronomics as Maintenance Treatment in Oncology: Time for Chemo-Switch ?
- Metronomics chemotherapy: time for computational decision support.
- Metronomics during palliative care in paediatric oncology? For sure! But handle me with care
- Metronomics maintenance for HGNET-BCOR tumors of the cerebellum
- Metronomics — fulfilling unmet needs beyond level A evidence
- Metronomics: intrinsic anakoinosis modulator ?
- Metronomics: towards personalized chemotherapy?
- Modeling the Impact of Anticancer Agents on Metastatic Spreading
- Moving forward with metronomic scheduling of anti-cancer treatment: Meeting report of the 2nd international workshop on metronomic and antiangiogenic chemotherapy in paediatric oncology
- Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic Meeting May 2016, Mumbai
- Paediatric metronomic four-drug metronomic regimen has anti-tumour activity in pediatric low-grade glioma; the results of a phase II clinical trial.
- Phase I Study of a Combination of Fluvastatin and Celecoxib in Children with Relapsing/Refractory Low-Grade or High-Grade Glioma (FLUVABREX)
- PK/PD-based mathematical modeling identifies an optimal protocol for metronomic chemotherapy
- Preliminary evaluation of children treated with metronomic chemotherapy and valproic acid in a low-income country: Metro-Mali-02.
- Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment
- Retrospective National “Real Life” Experience of the SFCE with the Metronomic MEMMAT and MEMMAT-Like Protocol
- Revisiting metronomic vinorelbine with mathematical modelling:
- SFCE-METRO01 four-drug metronomic regimen phase II trial for pediatric extracranial tumor
- Successfully targeting the cancer system with metronomics for medulloblastoma
- Sustained Complete Response to Metronomic Chemotherapy in a Child with Refractory ATRT
- Synthesis of novel isoflavene-propranolol hybrids as anti-tumor agents
- Targeted therapy with propranolol and metronomic chemotherapy combination: sustained complete response of a relapsing metastatic angiosarcoma
- β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma.
- ‘Hard’ Drug Repurposing for Precision Oncology: the Missing Link?
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Papers of Interest
Sections
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Global Oncology
- Can We Treat Cancer for a Dollar a Day? Guidelines for Low-Income Countries
- Bending the cost curve in cancer care.
- CANCER CONTROL OPPORTUNITIES IN LOW- AND MIDDLE-INCOME COUNTRIES
- Cancer in the developing world: can we avoid the disaster?
- Challenges for paediatric oncology in Africa
- Delivery of cancer care in rural India: Experiences of establishing a rural comprehensive cancer care facility
- Effect of corruption on medical care in low-income countries
- Facing a “Slow-Motion Disaster” — The UN Meeting on Noncommunicable Diseases
- Metronomics — an alternative P4 medicine
- Moving cancer up the global health agenda
- Pediatric oncology research in low income countries: Ethical concepts and challenges
- Powerful Ideas for Global Access to Medicines
- Repurposing Approved and Abandoned Drugs for the Treatment and Prevention of Cancer through Public-Private Partnership
- Role of American Society of Clinical Oncology in Low- and Middle-Income Countries
- Treatment Abandonment is a Major Hurdle to Improving Survival in Childhood Cancer in the Developing World
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Metronomic in adult
- Cancer research, a field on the verge of a paradigm shift?
- metronomic temzolomide and propranol for refractory metastatic paraganglioma
- A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Are Beta Blockers New Potential Anticancer Agents?
- De-escalating cancer treatments during COVID 19 pandemic: Is metronomic chemotherapy a reasonable option?
- Drug Repurposing in Oncology—patient and health systems opportunities
- Editorial in JASA : Metronomic chemotherapy: an alternative and effective means of chemotherapy, ideal for developing countries.
- Evidence implicating immunological host effects in the efficacy of metronomic low-dose chemotherapy.
- Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy.
- Metformin as a Novel Component of Metronomic Chemotherapeutic Use: A Hypothesis
- Metronomic chemotherapy : new rationale for new direction
- Metronomic Chemotherapy : the book !
- Metronomic chemotherapy in advanced oral cancers
- Metronomic cyclophosphamide & anti-tumor immunity: tumor model & drug schedule dependence of gene responses and their regulators.
- Metronomic delivery of cyclophosphamide is less detrimental to granulosa cell viability, ovarian function, and fertility than MTD
- Metronomics@Mumbai2016 : special issue of the South Asian Journal of Cancer
- Paediatric cancer in low-income and middle-income countries
- Response assessment in metronomic chemotherapy: RECIST or PERCIST?
- Role of vascular normalization in benefit from metronomic chemotherapy.
- Special section on Metronomic Chemotherapy in Cancer Letters
- The anti-angiogenic basis of metronomic chemotherapy
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Metronomic in children
- Widely disseminated metastatic Ewing sarcoma: Sustained, complete metabolic response to first‐line oral metronomic chemotherapy
- A case of relapsing spinal atypical AT/RT responding to metronomic vinorelbine-cyclophosphamid-celecoxib.
- A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer
- A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic ewing sarcoma family of tumors
- Administration of temozolomide: comparison of conventional and metronomic chemotherapy regimens.
- Bevacizumab, With Sorafenib and Cyclophosphamide Provides Clinical Benefit for Recurrent or Refractory Osseous Sarcomas in Children and Young Adults
- Combination of metronomic cyclophosphamide and dietary intervention for neuroblastoma.
- Complete Remission and Long-term Survival in a Child With Relapsed Medulloblastoma With Extensive Osteosclerotic Bony Metastasis With a Novel Metronomic Chemobiological Approach.
- Cyclic Metronomic Chemotherapy for Pediatric Tumors: Six Case Reports and a Review of the Literature
- Desmoplastic small round cell tumors: role of metronomic maintenance
- Drug repurposing in pediatrics and pediatric hematology oncology.
- Effectiveness of metronomic chemotherapy in a child with medulloblastoma: A case report
- Improved Long-Term Survival of Patients with Recurrent Medulloblastoma Treated with a “MEMMAT-like” Metronomic Antiangiogenic Approach
- Intracranial desmoplastic small round cell tumor after childhood acute myeloid leukemia treated with metronomic oral cyclophosphamide
- Low-Dose Metronomic Topotecan and Pazopanib (TOPAZ) in Children with Relapsed or Refractory Solid Tumors: A C17 Canadian Phase I Clinical Trial
- Medication Errors on Oral Chemotherapy in Children With ALL in a Developing Country
- Metronomic Chemotherapy and Palliative Radiotherapy as Salvage Treatment of Refractory or Relapsed Pediatric Solid Tumors
- Metronomic Chemotherapy as a New Strategy for End-stage Pediatric Oncology Patients in Iran
- Metronomic Chemotherapy for Burkitt Lymphoma in a Patient With HIV
- Metronomic Chemotherapy in Pediatric Oncology: From Preclinical Evidence to Clinical Studies
- Metronomic Chemotherapy in Progressive Pediatric Malignancies: Old Drugs in New Package
- Metronomic Chemotherapy vs Best Supportive Care in Progressive Pediatric Solid Malignant Tumors: A Randomized Clinical Trial.
- Metronomic Maintenance Therapy in Refractory Acute Myeloblastic Leukemia with Monosomy 7
- Metronomic therapy for malignant peripheral nerve sheath tumor in NF1.
- Metronomic therapy in pediatric oncology: A snapshot.
- Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in Drug-Resistant Neuroblastoma Preclinical Models.
- Metronomics is as effective as current standard for recurrent high risk neuroblastoma
- More on propranolol and neuroblastoma
- Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World?
- Oral etoposide and cyclophosphamide: A low-cost palliative metronomic chemotherapy in advanced pediatric cancers
- Oral Metronomic Maintenance Therapy Can Improve Survival in High-Risk Neuroblastoma Patients Not Treated with ASCT or Anti-GD2 Antibodies
- Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma Preclinical Models.
- Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors
- Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children with relapsed/refractory solid tumors.
- Phase II metronomic Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma
- Propranolol a new drug against Rhabdomyosarcoma ?
- Propranolol in pediatric tumors : Presentation of 4 cases
- Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma
- Response of Relapsed Pancreatoblastoma to a Metronomic Vinorelbine-Cyclophosphamide Combination
- Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment
- Retrospective Analysis of Outcomes of Patients with Relapsed, Refractory and Metastatic Sarcomas who have received Metronomic Chemotherapy.
- Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells.
- SFCE-Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour
- Successful palliation of metastatic medulloblastoma with oral etoposide and risedronate
- Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child.
- Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen A Nonrandomized Controlled Trial
- Terapia metronomica: una opcion para el control del cancer en pacientes en tratamiento de intencion no curativa
- Treatment of Langerhans cell histiocytosis with a modified risk-adapted metronomic protocol-experience from India.
- vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma: a multicentre, open-label, randomised, phase 3 trial.
- ¿Puede la quimioterapia metronómica mejorar la sobrevida libre de progresión y sobrevida global en pacientes pediátricos con sarcomas avanzados?: Experiencia preliminar. Can metronomic chemotherapy improve PFS and OS in pediatric patients with advanced sarcomas ?
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Global Oncology
News items
- results of the MEMMAT trial out in Jama Oncol
- Maintenance chemotherapy in children with ALL is indeed metronomic chemotherapy
- Betablockers and neuroblastoma
- MGHI in the Lancet Oncology
- 2 new MGHI publications
- A new MGHI publication
- A new MGHI publication
- New MGHI publication on drug repositioning
- First official Metronomics Global Health Initiative publication
