An editorial entitled : Slow and Steady Keeps Them in the Race: Metronomic Therapy in Children With Cancer by SIDHARTH TOTADRI from the Pediatric Hematology-Oncology Unit, Department of Pediatrics, Christian Medical College and Hospital, Vellore, India has just been published in Indian Pediatrics.

It highlights the recent ancillary associated pediatric trial published in Jama Oncololgy (Pramanik R et al. Metronomic chemotherapy vs best supportive care in progressive pediatric solid malignant tumors: A randomized clinical trial. JAMA Oncol. 2017;3:1222-7.

In this ancillary study, no angiogenic biomarkers were identified but an decrease in TPS1 was observed in responders and an increase in non responders; confirming the role of angiognenesis on the anticancer effect of metronomic chemotherapy.

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