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Metronomic in children

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A case of relapsing spinal atypical AT/RT responding to metronomic vinorelbine-cyclophosphamid-celecoxib.

A recent case report entitled "A case of relapsing spinal atypical AT/RT responding to metronomic vinorelbine-cyclophosphamid-celecoxib" has just been published in Childs Nerv Sys by Gotti G, Biassoni V, Schiavello E, Spreafico F, Antonelli M, Calareso G, Pecori E, Gandola L, and Massimino M. from the Pediatric Unit of the Fondazione IRCCS Istituto (...)

A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer

Nathan J. Robison from Mark Kieran’s group in Boston just published a report of a phase II 5 drug regimen built upon the pioneer "4 drug regimen" published 8 years ago. The article is entitled "A phase II trial of a multi-agent oral anti-angiogenic (metronomic) regimen in children with recurrent or progressive cancer" was designed to evaluate the (...)

A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic ewing sarcoma family of tumors

In an article published very recently in Pediatric Blood and Cancer by the COG entitled : A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multiagent chemotherapy for patients with newly diagnosed metastatic ewing sarcoma family of tumors: A Children’s Oncology Group (COG) phase II study (NCT00061893) that aimed at (...)

Administration of temozolomide: comparison of conventional and metronomic chemotherapy regimens.

Houy N, and Le Grand F from the University of Lyon, Lyon, France; the CNRS, GATE Lyon Saint-Etienne, France and the emlyon business school, Écully, France and ETH Zurich, Zurich, Switzerland have published in the Journal of Theoretical Biology a research article entilted : Administration of temozolomide: comparison of conventional and metronomic (...)

Combination of metronomic cyclophosphamide and dietary intervention for neuroblastoma.

Morscher RJ, Aminzadeh-Gohari S Hauser-Kronberger C, Feichtinger RG, Sperl W, and Kofler B from the Laura Bassi Centre of Expertise-THERAPEP, Department of Pediatrics, Paracelsus Medical University, the Division of Medical Genetics, Medical University Innsbruck, the Department of Pathology, Paracelsus Medical University and the Department of (...)

Complete Remission and Long-term Survival in a Child With Relapsed Medulloblastoma With Extensive Osteosclerotic Bony Metastasis With a Novel Metronomic Chemobiological Approach.

The Tata Memorial Hospital in Mumbai has just published a interesting case report of a child with a relapsing medduloblastoma with extraneural metastasis who was successfully treated with a metronomic combination for 18 months.

Desmoplastic small round cell tumors: role of metronomic maintenance

in a recent work entitled Desmoplastic small round cell tumors: Multimodality treatment and new risk factors, published in Cancer Medicine, Scheer and al. from the Cooperative Weichteilsarkom Studiengruppe [CWS] report the analyse of 60 DSRCT patients Presentation The median age of 60 patients was 14.5 years. Male:female ratio was 4:1. Tumors were (...)

Drug repurposing in pediatrics and pediatric hematology oncology.

In this review article to published online in Drug Discovery Today, J Blatt and SJ Corey from the University of North Carolina, USA explore the scope of drug repurposing in pediatric hematology oncology and highlight its potential. Drug repurposing in pediatrics and pediatric hematology oncology. lBatt J, Corey SJ. Drug Discov Today. 2012 Jul 23. (...)

Medication Errors on Oral Chemotherapy in Children With ALL in a Developing Country

Sapna Oberoi, Amita Trehan and Ram Kumar Marwaha from the Division of Haematology/Oncology in The Hospital for Sick Children,Toronto, Canadaa nd from the Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India have just published in Pediatric Blood and Cancer an article entitled Medication Errors on Oral (...)

Metronomic Chemotherapy and Palliative Radiotherapy as Salvage Treatment of Refractory or Relapsed Pediatric Solid Tumors

In a recent article published in Current Oncology entitled Metronomic Chemotherapy and Palliative Radiotherapy as Salvage Treatment of Refractory or Relapsed Pediatric Solid Tumors A.M. Ali and M.I. El-Sayed from the Department of Radiotherapy and Nuclear Medicine, South Egypt Cancer Institute, Assiut University, Al-methak Street, Assiut, Egypt (...)