Sharada Mailankody, Jyoti Bajpai, Vishwapriya Godkhindi, Akshay Bedmutha, Shripad Banavali from the Tata Memorial Hospital have published in Pediatric Blood Cancer a case report entitled "Widely disseminated metastatic Ewing sarcoma: Sustained, complete metabolic response to first‐line oral metronomic chemotherapy".

An adult patient with an highly metastatic Ewing sarcoma received up-front metronomic chemotherapy with cyclophosphamide and etoposide both at 50 mg/m2 once daily dose (capping at 50 mg) for 21 days and tamoxifen (20 mg/m2 with cap at 20 mg twice daily) repeated every 28 days.

Interstingly, sequential FDG PET/CT scans over 3 years demonstrated partial metabolic response in primary and complete metabolic response (CMR) in the metastatic sites and post 3 years CMR at all sites. The high cumulative doses of Cy and Eto (over 5 g each) lead to the decision to stop the metronomic treatment and observe. At the last follow‐up, 4.5 years from diagnosis, he is alive without any disease.