Sondhi V, Arun Kurkure P, Jalali R, Rangarajan V, Sridhar E, Medhi S, Arora B. Source

J Pediatr Hematol Oncol. 2012 Jan 16. [Epub ahead of print]

Complete Remission and Long-term Survival in a Child With Relapsed Medulloblastoma With Extensive Osteosclerotic Bony Metastasis With a Novel Metronomic Chemobiological Approach.

Departments of Pediatric Oncology, Radiation Oncology, Bioimaging, Pathology, Radiodiagnosis, Tata Memorial Hospital, Mumbai, India.

Abstract

Extraneural metastases in medulloblastoma are rare. We report a boy with medulloblastoma who was initially treated with gross total excision of primary tumor followed by radiotherapy. Six years later, he developed disseminated osteosclerotic bony relapse associated with bone marrow involvement. He was successfully salvaged with metronomic low-dose cyclophosphamide, etoposide, and zoledronic acid. In patients with medulloblastoma and bone pain, metastases to bone should be excluded, and medulloblastoma should be considered while investigating osteosclerotic bone lesions. Furthermore, metronomic chemotherapy should be considered in this setting until better therapeutic modalities emerge.