The 1st LATIN AMERICAN MEETING IN METRONOMIC CHEMOTHERAPY AND DRUG REPOSITIONING IN ONCOLOGY will take place in ROSARIO, ARGENTINA, from MAY 27 to 28, 2016.

PRESIDENT O. Graciela Scharovsky

ORGANISING COMMITTEE Viviana R. Rozados (Chairperson) Herman A. Perroud María José Rico Mauricio Menacho Máquez Leandro E. Mainetti

SCIENTIFIC COMMITTEE O. Graciela Scharovsky (Argentine) Viviana R. Rozados (Argentine) Carlos M. Alasino (Argentine) Nicolas André (France) Jaume Mora Graupera (Spain)

INVITED LECTURERNICOLAS ANDRÉ- Hopital pour Enfants de la Timone- Marseille, France; Metronomic Global Health Initiative

INVITED SPEAKERS JAUME MORA GRAUPERA (Barcelona, Spain) NORMA ESTHELA LLAMAS PEREGRINA (Mexico) WENDY GÓMEZ GARCÍA (Dominican Republic) HERMAN PERROUD (Argentine) CARLOS M. ALASINO (Argentine) VIVIANA R. ROZADOS (Argentine) MARÍA JOSÉ RICO (Argentine) MAURICIO MENACHO MÁRQUEZ (Argentine) LEANDRO MAINETTI (Argentine) PAULA SCHAIQUEVICH (Argentine) ANDREZA ALMEIDA SENERCHIA (Brasil) OSCAR ARRIETA (Mexico) MILENA VILLARROEL (Chile) LAURO GREGIANIN (Brasil) ADRIANA ROSE (Argentine) SIDNEI EPELMAN (Brasil)

PROGRAMMEOPENING CEREMONY O.G. SCHAROVSKY - Welcome and introduction

OPENING LECTURE N. ANDRÉ - Metronomic chemotherapy. MGHI and its proposal for low and middle income countries

SESSION 1: PRE-CLINIC EXPERIENCE VIVIANA R. ROZADOS - Metronomic chemotherapy for lymphomas and sarcomas LEANDRO E. MAINETTI - Metronomic chemotherapy with cyclophosphamide plus celecoxib or doxorubicin, for mammary adenocarcinomas. MAURICIO MENACHO MÁRQUEZ - Metronomic chemotherapy with metformin plus propranolol for mammary adenocarcinomas. MARÍA J. RICO - Metronomic chemotherapy. Comparative efficacy of three combined treatments. PAULA SCHAIQUEVICH - In vitro studies of chemotherapy agents for the treatment of retinoblastomas.

SESSION 2: CLINIC EXPERIENCE IN PEDIATRIC CANCER WENDY GÓMEZ GARCÍA – Experience report: palliative care programme & metronomic chemotherapy in the Hemato-Oncology service in the Hospital Infantil Dr. Robert Reid Cabral, Santo Domingo, Dominican Republic, from January 2012 to January 2015. JAUME MORA GRAUPERA – Maintenance treatment for patients with high risk Ewing sarcoma. MILENA VILLARROEL - Metronomic chemotherapy for Ewing Sarcoma. Theoretical bases for the GALOP Protocol. LAURO GREGIANIN - Metronomic chemotherapy for localized Ewing Sarcoma. Results of the GALOP Protocol. ADRIANA ROSE - Metronomic chemotherapy for metastatic Ewing Sarcoma. Results of the GALOP Protocol. SIDNEI EPELMAN - The role of metronomic treatment in children and adolescents with brain tumor. NORMA ESTHELA LLAMAS PEREGRINA – Spiritual and emotional impact of metronomic chemotherapy in the patient and the family.

SESSION 3: CLINIC EXPERIENCE IN ADULT CANCER CARLOS M. ALASINO - Metronomic chemotherapy for advanced breast cancer patients. Clinical outcomes. HERMAN A. PERROUD – Metronomic chemotherapy for advanced breast cancer patients. Biomarkers and quality of life. ANDREZA ALMEIDA SENERCHIA - Results of metronomic therapy for osteosarcoma patients: a report from the Latin American osteosarcoma treatment group. DANIEL ALONSO - Desmopressin as perioperative adjuvant and hemostatic agent in oncology

SUMMARY AND PERSPECTIVES : GUILLERMO CHANTADA

CONCLUDING REMARKS: O. GRACIELA SCHAROVSKY

the updated program can be find in the attached file