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Cancer research, a field on the verge of a paradigm shift?

Tuesday 26 June 2012 ⋅ Reply to this article

In this perspective piece, Ido Goldstein, Shalom Madar et Varda Rotter from the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot , Israel, analyze the roots of the paradigm on which cancer research is based. Then, they propose that the field of cancer research would benefit from integrating normal and "out of the box"theories to generate a new research framework, to fasten progress and reduce cancer-related deaths. Interestingly, the authors highlight "cancer as a chronic disease" and "low dose chemotherapy" as part of the potential changes to be brought to the cancer research paradigm shift they call upon.

You can read the acces the full text of this article (Cancer research, a field on the verge of a paradigm shift? Trends in Molecular Medicine, Volume 18, Issue 6, June 2012, Pages 299–303) here

Cancer research, a field on the verge of a paradigm shift?

Ido Goldstein, Shalom Madar Varda Rotter

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot , Israel,

Trends in Molecular Medicine, Volume 18, Issue 6, June 2012, Pages 299–303

Abstract

The theoretical framework for the field of cancer research is based on two main principles. The first is that cancer advances in a stepwise manner, with each alteration driving cells further toward a malignant state. Second, to cure cancer we must target only cancer-specific properties. Here, we analyze the birth and propagation of the cancer research paradigm. We believe the current paradigm is immersed in crisis and that the field would benefit from integrating theories within and outside the normal modes of research to compile a new framework, with the hope of faster progress and significantly fewer cancer-related deaths.