Metronomics Global Health Initiative

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the e-cancer/MGHI "metronomic" interviews series

The Ecancer website has released the videos of the "ecancer/MGHI metronomic interviews series" that have been shoot during the 4th metronomic meeting that took place in Mliano last June. The following interviews are available :

- Dr Nicolas André from the Hôpital pour Enfants de La Timone and MGHI, Marseille, France talks about the use of metronomic chemotherapy in frail and unfit patients, as well as its benefits as an orally administered treatment and one that is cost-effective for low income countries. In particular, he discusses the aims and work of the Metronomic Global Health Initiative. In addition, he notes the strides being made in drug repurposing.

- Pr Guido Bocci from University of Pisa, Pisa, Italy talks t about the benefits of metronomic treatment and alos highlights the difficulties faced in trying to find biomarkers or funding.

- Dr Alexandru Eniu from the Cancer Institute Ion Chiricuta Cluj-Napoca, Cluj-Napoca, Romania talks about the treatment of cancer in low and middle income countries with a particular focus on breast cancer.

- Pr Yuval Shaked from the Israel Institute of Technology, Haifa, Israel talks about the benefits of a metronomic chemotherapy regimen as a less aggressive treatment than high dose chemotherapy and a more effective maintenance drug, preventing relapse and decreasing metastic burden and highlights the differences in host response following metronomic chemotherapy.

- Dr Lisa Hutchinson, - Editor of Nature Reviews, London, UK talks about the benefits of metronomic chemotherapy and drug repurposing, whilst noting the challenges facing it such as a lack of rigorous definitions and terminology, limited knowledge about dosage efficacy, and difficulties surrounding funding. She also talk about talks about the work of her journal, Nature Review Clinical Oncology.

- Pr Shripad Banavali from the Tata Memorial Hospital, Mumbai, India talks about drug repurposing to overcome economic difficulties in global cancer care

Three interviews then deals with neuroblastoma.

- Pr Jaroslav Sterba from the University Children’s Hospital Brno, Brno, Czech Republic talks about the benefits of metronomic therapy in treating neuroblastoma. He also discusses metronomics can be combined with other treatment strategies such as immunotherapy.

- Pr Frank Berthold from University Hospital Köln, Köln, Germany talks about the use of metronomic therapy in treating children with neuroblastoma.

- Dr Eddy Pasquier from the Children’s Cancer Institute Australia, Randwick, Australia talks about drug repurposing with emphasis on the use of betablockers, previously used as antihypertensive drugs, in combination with chemotherapy to treat neuroblastoma.

- Dr Gauthier Bouche from Anticancer Fund, Strombeek-Bever, Belgium talks about repurposing generics molecules to fight cancer and the work of the REDO project.

- Lastly, Pr Francesco Bertolini from the European Institute of Oncology, Milan, Italy talks about metronomic therapy and drug repurposing and highlight the potential use of metformin, formerly used in diabetes, to treat breast cancer,.

The videos can aslo be found[here] on the ecancer website or on youtube.