Nat Rev Clin Oncol. 2010 Aug;7(8):455-65. Epub 2010 Jun 8. Metronomic chemotherapy: new rationale for new directions. Pasquier E, Kavallaris M, André N. Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer. The key involvement of angiogenesis in tumor growth and metastasis has started to redefine chemotherapy and new protocols have emerged. Metronomic chemotherapy, which is intended to prevent tumor angiogenesis, is based on more frequent and low-dose (...)