Summary Childhood low-grade glioma (LGG) is the most common paediatric central nervous system (CNS) neoplasm. Among LGG hypothalamo-chiasmatic gliomas (HCG) remain a genuine therapeutic challenge. One of the aims of the treatment is to control tumour growth while trying to delay or avoid the use of radiotherapy. Thus chemotherapy is accepted as a first line treatment when surgery is not possible in children aged less than 5 years old and several lines of treatment are usually necessary to (...)