In this perspective piece, Ido Goldstein, Shalom Madar et Varda Rotter from the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot , Israel, analyze the roots of the paradigm on which cancer research is based. Then, they propose that the field of cancer research would benefit from integrating normal and "out of the box"theories to generate a new research framework, to fasten progress and reduce cancer-related deaths. Interestingly, the authors highlight "cancer (...)