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Metronomic in children
Phase II metronomic Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma
A recent artivle published inthe JCO by Alvaro Lassaletta and al. report on the use of metronomic weekly vinblastine in 54 children with naive LGG.Five-year overall survival and progression-free survival (PFS) rates were 94% and 53% respectively, for the entire cohort with better outcome for NF1 patients. Treatment was well tolerated and quality of[...]
Propranolol a new drug against Rhabdomyosarcoma ?
In a recent "letter to the editor" in press in the Journal of Pediatric Hematology/Oncology Rojina Shilpakar, Gottfried Lemperle, and Thomas Mentzel from respectively the Sushma Koirala Memorial Hospital, Sakhu-Kathmandu, Nepal, the Division of Plastic Surgery, San Diego School of Medicine, University of California, and Frankfurt am Main Institute[...]
Propranolol in pediatric tumors : Presentation of 4 cases
During the last SIOP meeting in Toronto, F. Sarialioglu and al. from the Baskent University Faculty of Medicine in Ankara Turkey preented their preliminary experience with propranolol in pedaitric solid tumours.
We copy bellow the abstract available in the dedicated volume of Pediatric Blood and Cancer
PROPRANOLOL IN TUMORS EXCEPT INFANTILE[...]
Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma
The Pediatric Blood & Cancer journal has just released an interesting report about the use of a metronomic maintenance in children with pediatric diffuse intrinsic pontine gliomas (DIPGs). In the article entitled Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and[...]
Real-life experience with a "modified-MEMMAT" regimen for relapsed medulloblastoma
Thus a retrospective work lead by the Bambino Gesù Children’s Hospital in Roma evaluating MEMMAT like combinations in medulloblastoma. The article is entitled : Experience with a "modified-MEMMAT" regimen for relapsed medulloblastoma and has been published in Ther Adv Med Oncol.
The authors (Antonella Cacchione, Giada Del Baldo, Federica D’Antonio,[...]
Response of Relapsed Pancreatoblastoma to a Metronomic Vinorelbine-Cyclophosphamide Combination
Dhamne Chetan, Herzog Cynthia from the Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, the Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore and The University of Texas MD Anderson Cancer Center, Houston, TX, USA have reported in the J Pediatr[...]
Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment
The Latin American Group of Osteosarcoma Treatment has just published in Cancer the results of a randomized trial, evaluation the addition of a metronomic maintenance for patients with a resectable, non metastatic osteosarcoma. The first author of the paper, Andreza A. Senerchia, is one of our MGHI member. Although, at last follow-up, EFS with MAP plus[...]
Results of the Latin American Pediatric Oncology Group (GALOP) Trial for Patients With Metastatic Ewing Sarcoma: Multicentric Study of Interval-Compressed Multiagent and Metronomic Chemotherapy
Adriana Rose , Lauro Jose Gregianin , Erica Boldrini , Carla Macedo , Sima Ferman , Tatiana El Jaick Bonifácio Costa , Marcelo Scopinaro , Algemir Lunardi Brunetto , André Tesainer Brunetto , Milena Villarroel on behalf of the GALOP Latin American Pediatric Oncology Group Ewing Sarcoma Investigators have published in Pediatric Blood and Cancer the[...]
Retrospective Analysis of Outcomes of Patients with Relapsed, Refractory and Metastatic Sarcomas who have received Metronomic Chemotherapy.
Devadas SK, and Banavali S from the Ramaiah Medical College and Hospital, Department of Medical Oncology, Bengaluru, India. and the Tata Memorial Hospital, Department Of medical Oncology, Mumbai, India. have just published in the Gulf Journal of Oncology a retrospective study entitled: Retrospective Analysis of Outcomes of Patients with Relapsed,[...]
Safety and Efficacy of Vinorelbine and Continuous Low-Dose Cyclophosphamide Chemotherapy in Japanese Pediatric Patients With Relapsed or Refractory Rhabdomyosarcoma
The team from the Department of Pediatric Oncology, National Cancer Center Japan, Tokyo, Japan. and the Cancer Medicine, Cooperative Graduate School, The Jikei University Graduate School of Medicine, Tokyo, Japan have just published an article in Pediatric Blood and Cancer about a metronomic maitenance in RMS.
The authors Risa Yanai, Minako[...]
