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Metronomic in children
Propranolol a new drug against Rhabdomyosarcoma ?
In a recent "letter to the editor" in press in the Journal of Pediatric Hematology/Oncology Rojina Shilpakar, Gottfried Lemperle, and Thomas Mentzel from respectively the Sushma Koirala Memorial Hospital, Sakhu-Kathmandu, Nepal, the Division of Plastic Surgery, San Diego School of Medicine, University of California, and Frankfurt am Main Institute[...]
Propranolol in pediatric tumors : Presentation of 4 cases
During the last SIOP meeting in Toronto, F. Sarialioglu and al. from the Baskent University Faculty of Medicine in Ankara Turkey preented their preliminary experience with propranolol in pedaitric solid tumours.
We copy bellow the abstract available in the dedicated volume of Pediatric Blood and Cancer
PROPRANOLOL IN TUMORS EXCEPT INFANTILE[...]
Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma
The Pediatric Blood & Cancer journal has just released an interesting report about the use of a metronomic maintenance in children with pediatric diffuse intrinsic pontine gliomas (DIPGs). In the article entitled Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and[...]
Real-life experience with a "modified-MEMMAT" regimen for relapsed medulloblastoma
Thus a retrospective work lead by the Bambino Gesù Children’s Hospital in Roma evaluating MEMMAT like combinations in medulloblastoma. The article is entitled : Experience with a "modified-MEMMAT" regimen for relapsed medulloblastoma and has been published in Ther Adv Med Oncol.
The authors (Antonella Cacchione, Giada Del Baldo, Federica D’Antonio,[...]
Response of Relapsed Pancreatoblastoma to a Metronomic Vinorelbine-Cyclophosphamide Combination
Dhamne Chetan, Herzog Cynthia from the Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, the Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore and The University of Texas MD Anderson Cancer Center, Houston, TX, USA have reported in the J Pediatr[...]
Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment
The Latin American Group of Osteosarcoma Treatment has just published in Cancer the results of a randomized trial, evaluation the addition of a metronomic maintenance for patients with a resectable, non metastatic osteosarcoma. The first author of the paper, Andreza A. Senerchia, is one of our MGHI member. Although, at last follow-up, EFS with MAP plus[...]
Results of the Latin American Pediatric Oncology Group (GALOP) Trial for Patients With Metastatic Ewing Sarcoma: Multicentric Study of Interval-Compressed Multiagent and Metronomic Chemotherapy
Adriana Rose , Lauro Jose Gregianin , Erica Boldrini , Carla Macedo , Sima Ferman , Tatiana El Jaick Bonifácio Costa , Marcelo Scopinaro , Algemir Lunardi Brunetto , André Tesainer Brunetto , Milena Villarroel on behalf of the GALOP Latin American Pediatric Oncology Group Ewing Sarcoma Investigators have published in Pediatric Blood and Cancer the[...]
Retrospective Analysis of Outcomes of Patients with Relapsed, Refractory and Metastatic Sarcomas who have received Metronomic Chemotherapy.
Devadas SK, and Banavali S from the Ramaiah Medical College and Hospital, Department of Medical Oncology, Bengaluru, India. and the Tata Memorial Hospital, Department Of medical Oncology, Mumbai, India. have just published in the Gulf Journal of Oncology a retrospective study entitled: Retrospective Analysis of Outcomes of Patients with Relapsed,[...]
Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells.
Winter and al. have just published in PLoS One an article entitled Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells. in whihc they show that metronomic topotecan and melphalan are valid option for giving chemotherapy in retinoblastoma. This work is a collaboration between the[...]
SFCE-Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour
The Société Française des Cancers et leucémies de l’Enfant et de l’adolescent (SFCE) has recently published a very interesting metronomic phase II in children showing the efficacy of this regimen in children with relapsing RMS. Since vinorelbine can also be given orally, this paves the way for convinient treatments.
Phase II study of vinorelbine[...]
