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Metronomic in children
Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells.
Winter and al. have just published in PLoS One an article entitled Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells. in whihc they show that metronomic topotecan and melphalan are valid option for giving chemotherapy in retinoblastoma. This work is a collaboration between the[...]
SFCE-Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour
The Société Française des Cancers et leucémies de l’Enfant et de l’adolescent (SFCE) has recently published a very interesting metronomic phase II in children showing the efficacy of this regimen in children with relapsing RMS. Since vinorelbine can also be given orally, this paves the way for convinient treatments.
Phase II study of vinorelbine[...]
Successful palliation of metastatic medulloblastoma with oral etoposide and risedronate
This month in the ECCO website, the clinical case of the month reports on the use of metronomics for the palliative treatment of a child with bone metastasis of a medulloblastoma. The case is written by S. Wilne and al. from the Nottingham University Hospitals NHS Trust, United Kingdom. The metronomics treatment was based on oral etoposide for a year[...]
Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child.
Demlova and al. from the team of Jaroslav Sterba in Brno have recently published in Current Oncology a case report entitled : Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child.
They report a child with anaplastic oligodendroglioma of the[...]
Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen A Nonrandomized Controlled Trial
We are very excited to share the final results of the MEMMAT trial for the medullobastoma cohort- a gamme changer ! The results have been published by the JAMA Oncology journal. The article is entitled : Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen A Nonrandomized Controlled Trial MGHI is very proud[...]
Terapia metronomica: una opcion para el control del cancer en pacientes en tratamiento de intencion no curativa
We are very excited to proveid our first metronomic paper in spanish !
This short review entitled " Terapia metronomica: una opcion para el control del cancer en pacientes en tratamiento de intencion no curativa" has been written by Wendy Gomez Garcia, one our the MGHI members who works in the Hospital Infantil Dr. Robert Reid Cabral, Republica[...]
Treatment of Langerhans cell histiocytosis with a modified risk-adapted metronomic protocol-experience from India.
Narula G, Pradhan ND, Arora B, Banavali S .from the Pediatric Hematolymphoid Disease Management Group, Department of Medical Oncology, Tata Memorial Center, Mumbai, India have just published in Pediatric Blood and Cancer a research article entitled: Treatment of Langerhans cell histiocytosis with a modified risk-adapted protocol-experience from a[...]
vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma: a multicentre, open-label, randomised, phase 3 trial.
Giani Bisogno from the Haematology Oncology Division, Department of Women’s and Children’s Health, University of Padova, Padova, Italy on behalf of the the European paediatric Soft tissue sarcoma Study Group (EpSSG) have just pubisehd in the Lancet Oncology a randomized trial entitled: Vinorelbine and continuous low-dose cyclophosphamide as maintenance[...]
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