Metronomic chemotherapy is based on the chronic administration of chemotherapeutic agents at relatively low, minimally toxic doses, and with no prolonged drug-free breaks ■ Metronomic chemotherapy was originally developed to overcome drug resistance by shifting therapeutic target from tumor cells to tumor vasculature ■ In the past decade, several pilot and phase II clinical studies have established the potential efficacy and low toxicity of metronomic chemotherapy in adult and childhood (...)