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MGHI papers
Moving forward with metronomic scheduling of anti-cancer treatment: Meeting report of the 2nd international workshop on metronomic and antiangiogenic chemotherapy in paediatric oncology
Metronomic chemotherapy, which is defined by the frequent, repetitive administration of chemotherapeutic drugs at relatively low doses, and without prolonged drug-free break, is an emerging strategy to fight cancer. Initially thought to act by targeting tumour angiogenesis, additional mechanisms have been recently unveiled and metronomic (...)
Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic Meeting May 2016, Mumbai
The report from the last metronomic meeting that took place in Mumbai in May 2016 and organized by Pr Banavali has just been published in Ecancermedical Sciences. Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6–8 May 2016, Mumbai ABSTRACT The 5th Biennial Metronomic (...)
Paediatric metronomic four-drug metronomic regimen has anti-tumour activity in pediatric low-grade glioma; the results of a phase II clinical trial.
The SFCE (French Society for children with Cancer) in collaboration with MGHI has just published the results of the metro-SFCE01 trial in Frontiers in Pharmacology. The article entitled "Paediatric metronomic four-drug metronomic regimen has anti-tumour activity in pediatric low-grade glioma; the results of a phase II clinical trial " authored by (...)
Phase I Study of a Combination of Fluvastatin and Celecoxib in Children with Relapsing/Refractory Low-Grade or High-Grade Glioma (FLUVABREX)
We are very glad to share the recent article reporting the Phase I Study of a Combination of Fluvastatin and Celecoxib in Children with Relapsing/Refractory Low-Grade or High-Grade Glioma (FLUVABREX) by Pierre Leblond ,Emmanuelle Tresch-Bruneel,Alicia Probst ,Nadège Néant,Caroline Solas ,Arthur Sterin,Thomas Boulanger,Isabelle Aerts,Cécile (...)
PK/PD-based mathematical modeling identifies an optimal protocol for metronomic chemotherapy
We are very proud to share our new paper about PK-PD modelling and metronomic chemotherapy. This article entitled : Pharmacokinetics and pharmacodynamics-based mathematical modeling identifies an optimal protocol for metronomic chemotherapy by Joseph Ciccolini, Dominique Barbolosi, Christophe Meille, Aurelie Lombard, Cindy Serdjebi, Sarah Giacometti, (...)
Preliminary evaluation of children treated with metronomic chemotherapy and valproic acid in a low-income country: Metro-Mali-02.
We are very please to announce that our preliminary experience with a combination of metronomic chemotherapy and the introduction of target therapies with valproic acid , as an repositioned HDAC inhibitor as just been published by the indian journal of cancer. The study was lead by Dr Fousseiny Traore in the pediatric oncology unit of Bamako in Mali. (...)
Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment
To propose new cheap and non toxic treatments to all, we recently worked on propranolol. We show here for the first time that propranolol can an potentiate the anti-angiogenic effects and anti-tumor efficacy of chemotherapy. You can read the full paper here in Oncotarget an open access journal
Retrospective experience of children with relapsed brain tumors treated with oral combination of axitinib and metronomic etoposide
Caroline Donzé, Gabriel Revon-Rivière, Morgane Pondrom, Arnauld Verschuur, Pierre Leblond, Nicolas André from the Pediatric Oncology Department of of the Hopital pour enfants de la Timone APHM Marseille, the IHOPE Lyon, the Pediatric Oncology Department , CHU Nice, and the Metronomic Global Health Initiative, France have just published a short article (...)
Retrospective National “Real Life” Experience of the SFCE with the Metronomic MEMMAT and MEMMAT-Like Protocol
Some more data about the MEMMAT approach for relapsing/refractorty pediatric brain tumors confirming the potential of MEMMAT after the recent publication from the Irene Slavc team !! Ideed, the Société Française de lutte contre les Cancers de l’Enfants et l’adolescent (SFCE) has just published in JCM. The article entitled : Retrospective National “Real (...)
Revisiting metronomic vinorelbine with mathematical modelling:
We are delighted to share our latest publication entitled : Revisiting metronomic vinorelbine with mathematical modelling: a Phase I trial in lung cancer that as just been published in Cancer Chemotherapy and Pharmacology by Barlesi and al. from Marseille Early Phases Cancer Trials Center CLIP2, the SMARTc Unit Centre de Recherche en Cancérologie de (...)
