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Metronomic in children
More on propranolol and neuroblastoma
More on propranolol and neuroblastoma Two recent studies published in the Journal of Pediatric Surgery and in Oncotarget have confirmed our work on the potential role of betablocker (Pasquier and al. Br J Cancer 2013) in the treatment of neuroblastoma. Indeed, Xu T and al. from the Department of Surgery of Children’s Hospital, Fudan University, (...)
Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World?
J Pediatr Hematol Oncol. 2011 Jan;33(1):1-3. Nontoxic, fiscally responsible, future of oncology: could it be beginning in the Third World? Klement GL, Kamen BA.
Oral etoposide and cyclophosphamide: A low-cost palliative metronomic chemotherapy in advanced pediatric cancers
An article entiled "Oral etoposide and cyclophosphamide: A low-cost palliative metronomic chemotherapy in advanced pediatric cancers" has just been published in Cancer Research, Statistics, and Treatment by Kiran Kumar, Venkatraman Radhakrishnan, Manikandan Dhanushkodi, Jayachandran, Perumal Kalaiyarasi, Nikita Mehra, Arun Rajan Kumar, Gangothri (...)
Oral Metronomic Maintenance Therapy Can Improve Survival in High-Risk Neuroblastoma Patients Not Treated with ASCT or Anti-GD2 Antibodies
Xiaofei Sun, Zijun Zhen, Zhuowei Liu and collaborators from the State Key Laboratory of Oncology in South China and Sun Yat-sen University Cancer Center, Guanghzou China have just published in Cancers the results from their clinical experience with metronomic maintenance in neuroblastoma entitled :Oral Metronomic Maintenance Therapy Can Improve (...)
Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma Preclinical Models.
Zhang L, Wu B, Baruchel S. from the New Agent and Innovative Therapy Program, and the Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canadahave published in Translational Oncology an artivle entitled : Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma (...)
Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors
In a recent paper entitled Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors and published in Cancer Chemotherapy Pharmacology, Sören Büsker, Walter Jäger, Stefan Poschner, Lisa Mayr , Valentin Al Jalali, Johannes Gojo, Amedeo A Azizi, Sami Ullah, Muhammad Bilal, Lobna El Tabei, Uwe (...)
Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children with relapsed/refractory solid tumors.
Vo KT, Karski EE, Nasholm NM, Allen S, Hollinger F, Gustafson WC, Long-Boyle JR, Shiboski S, Matthay KK, and DuBois SG1 from the Department of Pediatrics, UCSF Benioff Children’s Hospital, University of California, San Francisco School of Medicine, San Francisco, CA; the Department of Clinical Pharmacy, UCSF Benioff Children’s Hospital, University of (...)
Phase II metronomic Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma
A recent artivle published inthe JCO by Alvaro Lassaletta and al. report on the use of metronomic weekly vinblastine in 54 children with naive LGG.Five-year overall survival and progression-free survival (PFS) rates were 94% and 53% respectively, for the entire cohort with better outcome for NF1 patients. Treatment was well tolerated and quality of (...)
Propranolol a new drug against Rhabdomyosarcoma ?
In a recent "letter to the editor" in press in the Journal of Pediatric Hematology/Oncology Rojina Shilpakar, Gottfried Lemperle, and Thomas Mentzel from respectively the Sushma Koirala Memorial Hospital, Sakhu-Kathmandu, Nepal, the Division of Plastic Surgery, San Diego School of Medicine, University of California, and Frankfurt am Main Institute (...)
Propranolol in pediatric tumors : Presentation of 4 cases
During the last SIOP meeting in Toronto, F. Sarialioglu and al. from the Baskent University Faculty of Medicine in Ankara Turkey preented their preliminary experience with propranolol in pedaitric solid tumours. We copy bellow the abstract available in the dedicated volume of Pediatric Blood and Cancer PROPRANOLOL IN TUMORS EXCEPT INFANTILE (...)
