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Metronomic in children
Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma
The Pediatric Blood & Cancer journal has just released an interesting report about the use of a metronomic maintenance in children with pediatric diffuse intrinsic pontine gliomas (DIPGs). In the article entitled Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and (...)
Response of Relapsed Pancreatoblastoma to a Metronomic Vinorelbine-Cyclophosphamide Combination
Dhamne Chetan, Herzog Cynthia from the Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, the Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore and The University of Texas MD Anderson Cancer Center, Houston, TX, USA have reported in the J Pediatr (...)
Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment
The Latin American Group of Osteosarcoma Treatment has just published in Cancer the results of a randomized trial, evaluation the addition of a metronomic maintenance for patients with a resectable, non metastatic osteosarcoma. The first author of the paper, Andreza A. Senerchia, is one of our MGHI member. Although, at last follow-up, EFS with MAP plus (...)
Retrospective Analysis of Outcomes of Patients with Relapsed, Refractory and Metastatic Sarcomas who have received Metronomic Chemotherapy.
Devadas SK, and Banavali S from the Ramaiah Medical College and Hospital, Department of Medical Oncology, Bengaluru, India. and the Tata Memorial Hospital, Department Of medical Oncology, Mumbai, India. have just published in the Gulf Journal of Oncology a retrospective study entitled: Retrospective Analysis of Outcomes of Patients with Relapsed, (...)
Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells.
Winter and al. have just published in PLoS One an article entitled Schedule-Dependent Antiangiogenic and Cytotoxic Effects of Chemotherapy on Vascular Endothelial and Retinoblastoma Cells. in whihc they show that metronomic topotecan and melphalan are valid option for giving chemotherapy in retinoblastoma. This work is a collaboration between the (...)
SFCE-Phase II study of vinorelbine and continuous low doses cyclophosphamide in children and young adults with a relapsed or refractory malignant solid tumour
The Société Française des Cancers et leucémies de l’Enfant et de l’adolescent (SFCE) has recently published a very interesting metronomic phase II in children showing the efficacy of this regimen in children with relapsing RMS. Since vinorelbine can also be given orally, this paves the way for convinient treatments. Phase II study of vinorelbine and (...)
Successful palliation of metastatic medulloblastoma with oral etoposide and risedronate
This month in the ECCO website, the clinical case of the month reports on the use of metronomics for the palliative treatment of a child with bone metastasis of a medulloblastoma. The case is written by S. Wilne and al. from the Nottingham University Hospitals NHS Trust, United Kingdom. The metronomics treatment was based on oral etoposide for a year (...)
Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child.
Demlova and al. from the team of Jaroslav Sterba in Brno have recently published in Current Oncology a case report entitled : Successful use of metronomic vinblastine and fluorothymidine pet imaging for the management of intramedullary spinal cord anaplastic oligoastrocytoma in a child. They report a child with anaplastic oligodendroglioma of the (...)
Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen A Nonrandomized Controlled Trial
We are very excited to share the final results of the MEMMAT trial for the medullobastoma cohort- a gamme changer ! The results have been published by the JAMA Oncology journal. The article is entitled : Sustained Survival Benefit in Recurrent Medulloblastoma by a Metronomic Antiangiogenic Regimen A Nonrandomized Controlled Trial MGHI is very proud (...)
Terapia metronomica: una opcion para el control del cancer en pacientes en tratamiento de intencion no curativa
We are very excited to proveid our first metronomic paper in spanish ! This short review entitled " Terapia metronomica: una opcion para el control del cancer en pacientes en tratamiento de intencion no curativa" has been written by Wendy Gomez Garcia, one our the MGHI members who works in the Hospital Infantil Dr. Robert Reid Cabral, Republica (...)
